Publications

Sun Lab members are shown in bold. *: co-first author; #: co-responding author. 

For a full list of publications, also see

Google Scholar: https://scholar.google.com/citations?user=ZIWyBZoAAAAJ&hl=en

NCBI Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/wei.sun.9/bibliography/public/

Preprints

The following preprints are earlier versions of subsequently published articles.

Co-Engineering Vapor-Deposited Polycationic Microenvironment and Immobilization Strategy to Enhance β-Galactosidase Kinetics at Acidic pH.
Fianu F, Chen J, Gougerdchi B, Duan H, Huang H, Yang R, Sun W#, Cheng Y#.
ChemRxiv, February 2026.
Read preprint · Published version

Nanoscale Protonation Limits and Charge Density in Polymer Films Govern the Activity of Immobilized LacZ under Acid Stress.
Duan H*, Chen J*, Fianu F, Sun W#, Cheng Y#.
bioRxiv, January 2026.
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Research Articles

2026

Coengineering Vapor-Deposited Polycationic Microenvironments and Immobilization Strategy to Enhance β-Galactosidase Kinetics at Acidic pH.
Fianu F, Chen J, Faraji-Gougerdchi B, Duan H, Huang H, Yang R, Sun W#, Cheng Y.
ACS Omega 11, 50892–50907.
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Nanoscale protonation limits and charge density in polymer films govern the activity of immobilized LacZ under acid stress.
Duan H*, Chen J*, Fianu F, Sun W#, Cheng Y.
Nanoscale 18, 13769–13780.
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2023

Genetically encoded chemical crosslinking of RNA in vivo.
Sun W, Wang N, Liu H, Yu B, Jin L, Ren X, Shen Y, Wang L.
Nature Chemistry 15, 21–32.
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Genetically encoded chemical crosslinking of carbohydrate.
Li S, Wang N, Yu B, Sun W, Wang L.
Nature Chemistry 15, 33–42.
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2022

Accelerating PERx reaction enables covalent nanobodies for potent neutralization of SARS-CoV-2 and variants.
Yu B, Li S, Tabata T, Wang N, Cao L, Kumar GR, Sun W, Liu J, Ott M, Wang L.
Chem 8, 2766–2783.
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Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law.
Zou X, Schaefke B, Li Y, Jia F, Sun W, Li G, Liang W, Reif T, Heyd F, Gao Q, Tian S, Li Y, Tang Y, Fang L, Hu Y, Chen W.
Life Science Alliance 5, e202101333.
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2021

A Genetically Encoded Fluorosulfonyloxybenzoyl-L-lysine for Expansive Covalent Bonding of Proteins via SuFEx Chemistry.
Liu J, Cao L, Klauser PC, Cheng R, Berdan VY, Sun W, Wang N, Ghelichkhani F, Yu B, Rozovsky S, Wang L.
Journal of the American Chemical Society 143, 10341–10351.
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Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko M, Mikuda N, Höpken UE, Kärgel E, Uyar B, Tufan AB, Milanovic M, Sun W, Krahn I, Schleich K, von Hoff L, Hinz M, Willenbrock M, Jungmann S, Akalin A, Lee S, Schmidt-Ullrich R, Schmitt CA, Scheidereit C.
The EMBO Journal 40, e104296.
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2020

Pan-tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation.
Li Y, Schaefke B, Zou X, Zhang M, Heyd F, Sun W, Zhang B, Li G, Liang W, He Y, Zhou J, Li Y, Fang L, Hu Y, Chen W.
Molecular Systems Biology 16, e9367.
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FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Hu JL, Liang H, Zhang H, Yang MZ, Sun W, Zhang P, Luo L, Feng JX, Bai H, Liu F, Zhang T, Yang JY, Gao Q, Long Y, Ma XY, Chen Y, Zhong Q, Yu B, Liao S, Wang Y, Zhao Y, Zeng MS, Cao N, Wang J, Chen W, Yang HT, Gao S.
Nucleic Acids Research 48, 2733–2748.
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2019

Photocaged Quinone Methide Crosslinkers for Light-Controlled Chemical Crosslinking of Protein-Protein and Protein-DNA Complexes.
Liu J*, Cai L*, Sun W*, Cheng R, Wang N, Jin L, Rozovsky S, Seiple IB, Wang L.
Angewandte Chemie International Edition 58, 18839–18843.
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Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus.
Wang X, You X, Langer JD, Hou J, Rupprecht F, Vlatkovic I, Quedenau C, Tushev G, Epstein I, Schaefke B, Sun W, Fang L, Li G, Hu Y, Schuman EM, Chen W.
Nature Communications 10, 5009.
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2018

The IκB kinase complex is a regulator of mRNA stability.
Mikuda N, Kolesnichenko M, Beaudette P, Popp O, Uyar B, Sun W, Tufan AB, Perder B, Akalin A, Chen W, Mertins P, Dittmar G, Hinz M, Scheidereit C.
The EMBO Journal 37, e98658.
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Pervasive allele-specific regulation on RNA decay in hybrid mice.
Sun W*, Gao Q*, Schaefke B, Hu Y, Chen W.
Life Science Alliance 1, e201800052.
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2017

Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner.
Xu X, Meng Q, Erben U, Wang P, Glauben R, Kühl AA, Wu H, Ma CW, Hu M, Wang Y, Sun W, Jia J, Wu X, Chen W, Siegmund B, Qin Z.
Cellular & Molecular Immunology 14, 597–606.
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2016

Global analysis of regulatory divergence in the evolution of mouse alternative polyadenylation.
Xiao MS, Zhang B, Li YS, Gao Q, Sun W, Chen W.
Molecular Systems Biology 12, 890.
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Characterization of a Single Genomic Locus Encoding the Clustered Protocadherin Receptor Diversity in Xenopus tropicalis.
Etlioglu HE, Sun W, Huang Z, Chen W, Schmucker D.
G3: Genes, Genomes, Genetics 6, 2309–2318.
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A germline chromothripsis event stably segregating in 11 individuals through three generations.
Bertelsen B, Nazaryan-Petersen L, Sun W, Mehrjouy MM, Xie G, Chen W, Hjermind LE, Taschner PE, Tümer Z.
Genetics in Medicine 18, 494–500.
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2015

MLPA Application in Clinical Diagnosis of DMD/BMD in Shanghai.
Ji X, Zhang J, Xu Y, Long F, Sun W, Liu X, Chen Y, Jiang W.
Journal of Clinical Laboratory Analysis 29, 405–411.
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Extensive allele-specific translational regulation in hybrid mice.
Hou J, Wang X, McShane E, Zauber H, Sun W, Selbach M, Chen W.
Molecular Systems Biology 11, 825.
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Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing.
Gao Q*, Sun W*, Ballegeer M, Libert C, Chen W.
Molecular Systems Biology 11, 816.
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Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity.
You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W.
Nature Neuroscience 18, 603–610.
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A t(3;9)(q25.1;q34.3) translocation leading to OLFM1 fusion transcripts in Gilles de la Tourette syndrome, OCD and ADHD.
Bertelsen B, Melchior L, Jensen LR, Groth C, Nazaryan L, Debes NM, Skov L, Xie G, Sun W, Brøndum-Nielsen K, Kuss AW, Chen W, Tümer Z.
Psychiatry Research 225, 268–275.
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2014

Quantitative profiling of Drosophila melanogaster Dscam1 isoforms reveals no changes in splicing after bacterial exposure.
Armitage SA*, Sun W*, You X*, Kurtz J, Schmucker D, Chen W.
PLOS ONE 9, e108660.
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Polar bear encephalitis: establishment of a comprehensive next-generation pathogen analysis pipeline for captive and free-living wildlife.
Szentiks CA, Tsangaras K, Abendroth B, Scheuch M, Stenglein MD, Wohlsein P, Heeger F, Höveler R, Chen W, Sun W, Damiani A, Nikolin V, Gruber AD, Grobbel M, Kalthoff D, Höper D, Czirják GÁ, Derisi J, Mazzoni CJ, Schüle A, Aue A, East ML, Hofer H, Beer M, Osterrieder N, Greenwood AD.
Journal of Comparative Pathology 150, 474–488.
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2013

A novel endogenous betaretrovirus group characterized from polar bears (Ursus maritimus) and giant pandas (Ailuropoda melanoleuca).
Mayer J, Tsangaras K, Heeger F, Avila-Arcos M, Stenglein MD, Chen W, Sun W, Mazzoni CJ, Osterrieder N, Greenwood AD.
Virology 443, 1–10.
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A systematic evaluation of hybridization-based mouse exome capture system.
Gao Q, Sun W, You X, Froehler S, Chen W.
BMC Genomics 14, 492.
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Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing.
Sun W, You X, Gogol-Döring A, He H, Kise Y, Sohn M, Chen T, Klebes A, Schmucker D, Chen W.
The EMBO Journal 32, 2029–2038.
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Molecular prenatal diagnosis of autosomal recessive spinal muscular atrophies using quantification polymerase chain reaction.
Jiang W, Ji X, Xu Y, Qu X, Sun W, Yang Z, Tao J, Chen Y.
Genetic Testing and Molecular Biomarkers 17, 438–442.
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2011

Clinical application of multiplex ligation-dependent probe amplification for the detection of exonic copy number alterations in the Dystrophin gene.
Long F, Sun W, Ji X, Li XH, Liu XQ, Jiang WT, Tao J.
Chinese Journal of Medical Genetics 28, 699–704. Article in Chinese.
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Optimization of polymerase chain reaction assay combined with capillary electrophoresis to detect the pre- and full mutation of FMR1 gene.
Zhou Y, Sun W, Xiao B, Han X, Long F, Jiang WT, Ji X, Tao J.
Chinese Journal of Medical Genetics 28, 401–405. Article in Chinese.
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2010

Selection of short tandem repeats and their application in linkage analysis for prenatal diagnosis of spinal muscular atrophy.
Sun W, Shen JW, Long F, Ji X, Yang ZJ, Tao J.
Journal of Shanghai Jiao Tong University (Medical Science) 30(6), 707.
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Reviews

The next generation of lipid nanoparticles for in vivo engineering and targeted delivery.
Penghui Zhao, Zerui Zhou, Jie Chen, Wei Sun, Zhenhua Tian, Wujin Sun.
Nano Research 19(10), 94908949 (2026).
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The evolution of posttranscriptional regulation.
Schaefke B*, Sun W*, Li YS*, Fang L, Chen W.
WIREs RNA 9, e1485 (2018).
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Methods and Book Chapters

Metabolic Labeling of Newly Synthesized RNA with 4sU to in Parallel Assess RNA Transcription and Decay.
Sun W, Chen W.
Methods in Molecular Biology 1720, 25–34 (2018).
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